别孕烷醇酮
别孕烷醇酮(英語:,ALLO,也名为3α,5α-孕烷醇酮)是一种作用于大脑的神经甾体[2][3],可用于治疗产后抑郁症[3][4][5]。
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| 臨床資料 | |
|---|---|
| 商品名 | Zulresso |
| 其他名稱 | ALLO; Allo; ALLOP; AlloP; Brexanolone; SAGE-547; SGE-102; 5α-Pregnan-3α-ol-20-one; 3α-Hydroxy-5α-pregnan-20-one; 3α,5α-Tetrahydroprogesterone; 3α,5α-THP |
| 给药途径 | Intravenous infusion[1] |
| 藥物類別 | Neurosteroids; Antidepressants |
| 法律規範狀態 | |
| 法律規範 |
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| 藥物動力學數據 | |
| 血漿蛋白結合率 | >99%[1] |
| 药物代谢 | Non-CYP450 (keto-reduction via AKRs, glucuronidation via UGTs, sulfation via SULTs)[1] |
| 生物半衰期 | 9 hours[1] |
| 排泄途徑 | Feces: 47%[1] Urine: 42%[1] |
| 识别 | |
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| CAS号 | 516-54-1 |
| PubChem CID | |
| DrugBank | |
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| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| 化学 | |
| 化学式 | C21H34O2 |
| 摩尔质量 | 318.501 g/mol |
| 3D模型(JSmol) | |
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参考文献
- (PDF). [2019-05-26]. (原始内容存档 (PDF)于2020-11-12).
- Reddy DS. . Progress in Brain Research 186. 2010: 113–37. ISBN 9780444536303. PMC 3139029
. PMID 21094889. doi:10.1016/B978-0-444-53630-3.00008-7. |journal=被忽略 (帮助) - Commissioner, Office of the. . www.fda.gov. [21 March 2019]. (原始内容存档于2019-04-22) (英语).
- Frieder A, Fersh M, Hainline R, Deligiannidis KM. . CNS Drugs. March 2019, 33 (3): 265–282. PMID 30790145. doi:10.1007/s40263-019-00605-7.
- Wilkinson ST, Sanacora G. . Drug Discov. Today. February 2019, 24 (2): 606–615. PMID 30447328. doi:10.1016/j.drudis.2018.11.007.
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