多巴胺轉運體

多巴胺轉運體
識別號
别名	SLC6A3；, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS1
外部ID	OMIM：126455 MGI：94862 HomoloGene：55547 GeneCards：SLC6A3
相關疾病
	infantile parkinsonism-dystonia、物質使用疾患[1]
為以下藥物的標靶
	阿托莫西汀、丁氨苯丙酮、氯米帕明、去甲文拉法辛、右旋安非他命、右旋哌甲酯、gbr-12935、左旋米那普倫、馬吲哚、哌甲酯、(RS)-nomifensine、苯乙肼、西布曲明、曲米帕明、WIN35428、serdexmethylphenidate chloride、右旋哌甲酯、右旋安非他命、苯丙胺、liafensine、甲基苯丙胺、安非拉酮、馬吲哚、methylphenidate hydrochloride、dasotraline、diethylpropion hydrochloride、phenmetrazine hydrochloride[2]
基因位置（人类）
染色体	5號染色體[3]
终止	1,445,440 bp[3]
基因位置（小鼠）
染色体	小鼠13号染色体[4]
终止	73,726,791 bp[4]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• protein N-terminus binding; • dopamine:sodium symporter activity; • 金屬離子結合; • neurotransmitter:sodium symporter activity; • dopamine binding; • 血浆蛋白结合; • symporter activity; • monoamine transmembrane transporter activity; • 大分子复合物结合; • 蛋白酶結合; • signaling receptor binding; • protein phosphatase 2A binding;
細胞組分	• 細胞質; • integral component of membrane; • 膜; • 细胞膜; • integral component of plasma membrane; • cell surface; • 轴突; • flotillin complex; • neuronal cell body; • 脂筏模型; • presynapse; • neuron projection; • dopaminergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
生物學過程	• response to cocaine; • 前脉冲抑制; • response to organic cyclic compound; • locomotory behavior; • dopamine biosynthetic process; • response to nicotine; • 老化; • neurotransmitter biosynthetic process; • monoamine transport; • adenohypophysis development; • regulation of dopamine metabolic process; • response to iron ion; • sensory perception of smell; • dopamine uptake involved in synaptic transmission; • dopamine catabolic process; • dopamine transport; • positive regulation of multicellular organism growth; • response to cAMP; • 哺乳; • response to ethanol; • neurotransmitter transport; • dopamine uptake; • transmembrane transport; • neurotransmitter uptake;
	Sources:Amigo / QuickGO
直系同源
	6531
	13162
	ENSG00000142319; ENSG00000276996
	ENSMUSG00000021609
	Q01959
	Q61327
	NM_001044
	NM_010020
	NP_001035
	NP_034150
	維基數據

多巴胺轉運體（英語：，DAT；溶質載體家族6成員3（英語：，SLC6A3））是負責將神經遞質從突觸運輸回細胞質基質的跨膜蛋白。由多巴胺轉運體進行的再攝取是將多巴胺從突觸清除的主要機制，除了前額葉，在前額葉多巴胺由去甲腎上腺素轉運體回收[7]。

DAT與一些多巴胺相關的疾病有關, 包含注意力不足過動症、躁鬱症、重性抑郁障碍、酗酒。編碼 DAT 蛋白的基因位於人類第5號染色體，含有15個外显子，共64kbp長。

功能

DAT從突觸間隙移除多巴胺，運回細胞內而終止神經遞質的信號。它屬於一種integral membrane protein[8]。

參見

單胺轉運體
去甲腎上腺素轉運體
血清素轉運體
Glutamate transporter

參考資料

.
.
GRCh38: Ensembl release 89: ENSG00000142319、ENSG00000276996 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021609 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Carboni E, Tanda GL, Frau R, Di Chiara G. . J. Neurochem. 1990, 55 (3): 1067–70. PMID 2117046. doi:10.1111/j.1471-4159.1990.tb04599.x.
Schultz W. . J. Neurophysiol. 1998, 80 (1): 1–27. PMID 9658025.

外部連結

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[1] .

[2] .

[refGRCh38Ensembl-3] GRCh38: Ensembl release 89: ENSG00000142319、ENSG00000276996 - Ensembl, May 2017

[refGRCm38Ensembl-4] GRCm38: Ensembl release 89: ENSMUSG00000021609 - Ensembl, May 2017

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2117046-7] Carboni E, Tanda GL, Frau R, Di Chiara G. . J. Neurochem. 1990, 55 (3): 1067–70. PMID 2117046. doi:10.1111/j.1471-4159.1990.tb04599.x.

[Schultz-8] Schultz W. . J. Neurophysiol. 1998, 80 (1): 1–27. PMID 9658025.